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A practical guide to rational drug d...

Sun, Hongmao.

A practical guide to rational drug design

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	A practical guide to rational drug design/ Sun Hongmao.
作者:	Sun, Hongmao.
出版者:	Amsterdam :Woodhead Publishing, : c2015.,
面頁冊數:	1 online resource :ill. :
提要註:	This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes.
標題:	Drugs - Design. -
電子資源:	click for full text
ISBN:	9780081001059 (electronic bk.)

A practical guide to rational drug design
Sun, Hongmao.

A practical guide to rational drug design[electronic resource] /Sun Hongmao. - Amsterdam :Woodhead Publishing,c2015. - 1 online resource :ill. - Woodhead Publishing series in biomedicine ;number 81. - Woodhead Publishing series in biomedicine ;no. 76..

Includes bibliographical references and index.

This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes.

ISBN: 9780081001059 (electronic bk.)Subjects--Topical Terms:

232690
Drugs
--Design.Index Terms--Genre/Form:

228523
Electronic books.

LC Class. No.: RS420

Dewey Class. No.: 615.19

A practical guide to rational drug design
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