高雄醫學大學圖書館 |

語系/ Language: 繁體中文

登入

回首頁

Metabolic Reprogramming in Gut Micro...

Arizona State University.

Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics // Lingjun Li.
作者:	Li, Lingjun,
面頁冊數:	1 electronic resource (76 pages)
附註:	Source: Masters Abstracts International, Volume: 86-11.
提要註:	Microplastics (MPs), typically less than 5 mm in size, are widespread environmental pollutants that primarily result from the degradation of plastics and the release of products commonly used in daily life. As global plastic production continues to increase, the accumulation of MPs in ecosystems has raised significant concerns. These pollutants not only threaten environmental systems but also pose risks to human health, particularly by disrupting the relationship between humans and their gut microbiota. Research suggests that MPs could alter gut microbiota composition and function, potentially impacting microbial metabolic processes. To investigate this, three bacterial strains-Escherichia coli MG1655, Nissle 1917, and Lactobacillus rhamnosus-were exposed in vitro to varying concentrations (0-500 μg/mL) of 1 μm polystyrene MPs under controlled anaerobic conditions. The findings showed that MP exposure inhibited bacterial growth in a concentration-dependent manner. Metabolomic analysis, using LC-MS, identified significant changes in critical metabolic pathways, such as sulfur metabolism, amino sugar metabolism, and nucleotide sugar metabolism. In vivo analysis using gut microbiota from C57BL/6 mice further revealed significant shifts in microbial communities, with an increase in Lactobacillus and a decrease in Erysipelatoclostridium in MP-exposed groups. Metabolomics also revealed alterations in tryptophan metabolism and energy pathways. These results highlight MPs' potential to disrupt gut microbiota through metabolic changes, offering insights into their possible health impacts.
Contained By:	Masters Abstracts International86-11.
標題:	Environmental science. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31997298
ISBN:	9798314876404

Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics /
Li, Lingjun,

Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics /Lingjun Li. - 1 electronic resource (76 pages)

Source: Masters Abstracts International, Volume: 86-11.

Microplastics (MPs), typically less than 5 mm in size, are widespread environmental pollutants that primarily result from the degradation of plastics and the release of products commonly used in daily life. As global plastic production continues to increase, the accumulation of MPs in ecosystems has raised significant concerns. These pollutants not only threaten environmental systems but also pose risks to human health, particularly by disrupting the relationship between humans and their gut microbiota. Research suggests that MPs could alter gut microbiota composition and function, potentially impacting microbial metabolic processes. To investigate this, three bacterial strains-Escherichia coli MG1655, Nissle 1917, and Lactobacillus rhamnosus-were exposed in vitro to varying concentrations (0-500 μg/mL) of 1 μm polystyrene MPs under controlled anaerobic conditions. The findings showed that MP exposure inhibited bacterial growth in a concentration-dependent manner. Metabolomic analysis, using LC-MS, identified significant changes in critical metabolic pathways, such as sulfur metabolism, amino sugar metabolism, and nucleotide sugar metabolism. In vivo analysis using gut microbiota from C57BL/6 mice further revealed significant shifts in microbial communities, with an increase in Lactobacillus and a decrease in Erysipelatoclostridium in MP-exposed groups. Metabolomics also revealed alterations in tryptophan metabolism and energy pathways. These results highlight MPs' potential to disrupt gut microbiota through metabolic changes, offering insights into their possible health impacts.

English

ISBN: 9798314876404Subjects--Topical Terms:

524052
Environmental science.
Subjects--Index Terms:

Microplastics

Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics /
LDR:03033nam a22004333i 4500 001 391491
005 20251124054806.5
006 m o d
007 cr|nu||||||||
008 251208s2025 miu||||||m |||||||eng d
020 $a 9798314876404
035 $a (MiAaPQD)AAI31997298
035 $a AAI31997298
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Li, Lingjun, $e author. $3 524050
245 1 0 $a Metabolic Reprogramming in Gut Microbiota Exposed to Polystyrene Microplastics / $c Lingjun Li.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2025
300 $a 1 electronic resource (76 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Masters Abstracts International, Volume: 86-11.
500 $a Advisors: Gu, Haiwei Committee members: Shepard, Christina; DeWeese, Robin.
502 $b M.S. $c Arizona State University $d 2025.
520 $a Microplastics (MPs), typically less than 5 mm in size, are widespread environmental pollutants that primarily result from the degradation of plastics and the release of products commonly used in daily life. As global plastic production continues to increase, the accumulation of MPs in ecosystems has raised significant concerns. These pollutants not only threaten environmental systems but also pose risks to human health, particularly by disrupting the relationship between humans and their gut microbiota. Research suggests that MPs could alter gut microbiota composition and function, potentially impacting microbial metabolic processes. To investigate this, three bacterial strains-Escherichia coli MG1655, Nissle 1917, and Lactobacillus rhamnosus-were exposed in vitro to varying concentrations (0-500 μg/mL) of 1 μm polystyrene MPs under controlled anaerobic conditions. The findings showed that MP exposure inhibited bacterial growth in a concentration-dependent manner. Metabolomic analysis, using LC-MS, identified significant changes in critical metabolic pathways, such as sulfur metabolism, amino sugar metabolism, and nucleotide sugar metabolism. In vivo analysis using gut microbiota from C57BL/6 mice further revealed significant shifts in microbial communities, with an increase in Lactobacillus and a decrease in Erysipelatoclostridium in MP-exposed groups. Metabolomics also revealed alterations in tryptophan metabolism and energy pathways. These results highlight MPs' potential to disrupt gut microbiota through metabolic changes, offering insights into their possible health impacts.
546 $a English
590 $a School code: 0010
650 4 $a Environmental science. $3 524052
650 4 $2 96060 $a Toxicology. $3 185681
650 4 $2 96060 $a Microbiology. $3 187154
650 4 $2 96060 $a Nutrition. $3 192833
653 $a Microplastics
653 $a Environmental pollutants
653 $a Lactobacillus rhamnosus
653 $a Gut microbiota
690 $a 0570
690 $a 0410
690 $a 0768
690 $a 0383
710 2 $a Arizona State University. $b Nutrition. $e degree granting institution. $3 524051
720 1 $a Gu, Haiwei $e degree supervisor.
773 0 $t Masters Abstracts International $g 86-11.
790 $a 0010
791 $a M.S.
792 $a 2025
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31997298

筆 0 讀者評論

多媒體

評論

新增評論分享你的心得，請勿在此評論區張貼涉及人身攻擊、情緒謾罵、或內容涉及非法的不當言論，館方有權利刪除任何違反評論規則之發言，情節嚴重者一律停權，以維護所有讀者的自由言論空間。

Export

取書館別