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Medicinal chemistry of nucleic acids

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Medicinal chemistry of nucleic acids/ edited by Li He Zhang, Zhen Xi, Jyoti Chattopadhyaya.
其他作者:	Zhang, Li He.
出版者:	Hoboken, N.J. :John Wiley & Sons, : c2011.,
面頁冊數:	1 online resource.
附註:	Includes index.
提要註:	Covering all areas of the medicinal chemistry and therapeutic applications of nucleic acids, this book provides up-to-date coverage of the broad area of nucleic acid chemistry and biology. The book lays out the basic principles of medicinal chemistry of nucleic acids before focusing on the development and application of modified nucleosides and nucleotides in medicinal chemistry. Cutting-edge subjects for drug discovery like antisense, RNAi, and siRNA are also discussed, and help the target audience of chemists, pharmaceutical researchers, and academics understand the use of nucleic acid drugs to treat diseases.
標題:	Pharmaceutical chemistry. -
電子資源:	http://www.myilibrary.com?id=323990
ISBN:	9781118092804 (electronic bk.)

Medicinal chemistry of nucleic acids
Medicinal chemistry of nucleic acids[electronic resource] /edited by Li He Zhang, Zhen Xi, Jyoti Chattopadhyaya. - Hoboken, N.J. :John Wiley & Sons,c2011. - 1 online resource. - Wiley series in drug discovery and development. - Wiley series in drug discovery and development..

Includes index.

Includes bibliographical references and index.

Frontmatter -- Color Plates -- Recent Advances in Carbocyclic Nucleosides: Synthesis and Biological Activity / Jianing Wang, Ravindra K Rawal, Chung K Chu -- Structures and Functions of Nucleic Acids Modified With S, Se, and Te and Complexed with Small Molecules / Wen Zhang, Jia Sheng, Zhen Huang -- Unraveling of the NAD Cyclizing and Calcium Signaling Functions of Human CD38 / Hon Cheung Lee -- DNA and RNA Binding Small Molecules / Shibo Li, Zhen Xi -- G-Quadruplex DNA and its Ligands in Anticancer Therapy / Zhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, Lian-Quan Gu -- Molecular Modeling in Nucleic Acid-Targeted Drug Design / Lidan Sun, Hongwei Jin, Liangren Zhang, Lihe Zhang -- Structure of 10 b6 s23 DNAzyme in Complex with the Target RNA --A Progress Report on the Mechanism of RNA Cleavage by DNA Enzyme / Oleksandr Plashkevych, Jyoti Chattopadhyaya -- Labeling Oligonucleotides toward the Biomedical Probe / Il Joon Lee, Byeang Hyean Kim -- Locked Nucleic Acid Oligonucleotides toward Clinical Applications / Rakesh N Veedu, Jesper Wengel -- The Pharmacokinetics Research of Nucleic Acid Drugs / Shengqi Wang, Dandan Lu, Qingqing Wang, Haifeng Song, Chan Gao, Caihong Liu, Ying Wang -- Inducible RNAi and Drug Target Validation / Wei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng, Qiu-Chen He, Li-He Zhang, De-Min Zhou -- siRNA: The Specificity and off-Target Effects / Quan Du, Huang Huang, Zicai Liang -- Index -- Wiley Series in Drug Discovery and Development --

Covering all areas of the medicinal chemistry and therapeutic applications of nucleic acids, this book provides up-to-date coverage of the broad area of nucleic acid chemistry and biology. The book lays out the basic principles of medicinal chemistry of nucleic acids before focusing on the development and application of modified nucleosides and nucleotides in medicinal chemistry. Cutting-edge subjects for drug discovery like antisense, RNAi, and siRNA are also discussed, and help the target audience of chemists, pharmaceutical researchers, and academics understand the use of nucleic acid drugs to treat diseases.

ISBN: 9781118092804 (electronic bk.)

Standard No.: 9786613239907

Source: 10.1002/9781118092804Wiley InterSciencehttp://www3.interscience.wiley.comSubjects--Topical Terms:

240627
Pharmaceutical chemistry.
Index Terms--Genre/Form:

228523
Electronic books.

LC Class. No.: RS400 / .M438 2011

Dewey Class. No.: 615/.19

National Library of Medicine Call No.: QV 185

Medicinal chemistry of nucleic acids
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245 0 0 $a Medicinal chemistry of nucleic acids $h [electronic resource] / $c edited by Li He Zhang, Zhen Xi, Jyoti Chattopadhyaya.
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500 $a Includes index.
504 $a Includes bibliographical references and index.
505 0 $a Frontmatter -- Color Plates -- Recent Advances in Carbocyclic Nucleosides: Synthesis and Biological Activity / Jianing Wang, Ravindra K Rawal, Chung K Chu -- Structures and Functions of Nucleic Acids Modified With S, Se, and Te and Complexed with Small Molecules / Wen Zhang, Jia Sheng, Zhen Huang -- Unraveling of the NAD Cyclizing and Calcium Signaling Functions of Human CD38 / Hon Cheung Lee -- DNA and RNA Binding Small Molecules / Shibo Li, Zhen Xi -- G-Quadruplex DNA and its Ligands in Anticancer Therapy / Zhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, Lian-Quan Gu -- Molecular Modeling in Nucleic Acid-Targeted Drug Design / Lidan Sun, Hongwei Jin, Liangren Zhang, Lihe Zhang -- Structure of 10 b6 s23 DNAzyme in Complex with the Target RNA --A Progress Report on the Mechanism of RNA Cleavage by DNA Enzyme / Oleksandr Plashkevych, Jyoti Chattopadhyaya -- Labeling Oligonucleotides toward the Biomedical Probe / Il Joon Lee, Byeang Hyean Kim -- Locked Nucleic Acid Oligonucleotides toward Clinical Applications / Rakesh N Veedu, Jesper Wengel -- The Pharmacokinetics Research of Nucleic Acid Drugs / Shengqi Wang, Dandan Lu, Qingqing Wang, Haifeng Song, Chan Gao, Caihong Liu, Ying Wang -- Inducible RNAi and Drug Target Validation / Wei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng, Qiu-Chen He, Li-He Zhang, De-Min Zhou -- siRNA: The Specificity and off-Target Effects / Quan Du, Huang Huang, Zicai Liang -- Index -- Wiley Series in Drug Discovery and Development --
505 0 $a Recent advances in carbocyclic nucleosides : synthesis and biological activity / Jianing Wang, Ravindra K. Rawal, and Chung K. Chu -- Structures and functions of nucleic acids modified with S, Se, and Teand complexed with small molecules / Wen Zhang, Jia Sheng, and Zhen Huang -- Unraveling of the NAD cyclizing and calcium signaling functions of human CD38 / Hon Cheung Lee -- DNA and RNA binding small molecules / Shibo Li and Zhen Xi -- G-quadruplex DNA and its ligands in anticancer therapy / Zhi-shu Huang ... [et al.] -- Molecular modeling in nucleic acid targeted drug design / Lidan Sun ... [et al.] -- Structure of 10-23 DNAzyme in complex with the target RNA in silico : a progress report on the mechanism of RNA cleavage by DNA enzyme / Oleksandr Plashkevych and Jyoti Chattopadhyaya -- Labeling oligonucleotides towards the biomedical probe / Il Joon Lee and Byeang Hyean Kim -- Locked nucleic acid oligonucleotides towards clinical application / Rakesh N. Veedu and Jesper Wengel -- The pharmacokinetics researches of nucleic acid drugs / Shengqi Wang -- Inducible RNAi and drug target validation / Wei Xiong ... [et al.] -- SiRNA : the specificity and off-target effects -- Quan Du, Huang Huang, Zicai Liang.
520 $a Covering all areas of the medicinal chemistry and therapeutic applications of nucleic acids, this book provides up-to-date coverage of the broad area of nucleic acid chemistry and biology. The book lays out the basic principles of medicinal chemistry of nucleic acids before focusing on the development and application of modified nucleosides and nucleotides in medicinal chemistry. Cutting-edge subjects for drug discovery like antisense, RNAi, and siRNA are also discussed, and help the target audience of chemists, pharmaceutical researchers, and academics understand the use of nucleic acid drugs to treat diseases.
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