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Mechanistic toxicology :the molecula...

Boelsterli, Urs A., (1948-)

Mechanistic toxicology :the molecular basis of how chemicals disrupt biological targets /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Mechanistic toxicology :/ Urs A. Boelsterli.
Reminder of title:	the molecular basis of how chemicals disrupt biological targets /
Author:	Boelsterli, Urs A.,
Published:	New York :Informa Healthcare, : c2009.,
[NT 15000922]:	2nd ed.
Description:	399 p. :ill. ; : 25 cm.;
基督教聖經之智慧書導讀 :	The author provides an introduction to an important, but often neglected, area within the toxicological sciences. The text gives new insights into the processes and mechanisms underlying the toxicity of chemicals and explains how foreign compounds exert their potentially damaging effects on cells and tissues.
Subject:	Molecular toxicology. -
ISBN:	9780849372728 (hard) :

Mechanistic toxicology :the molecular basis of how chemicals disrupt biological targets /
Boelsterli, Urs A.,1948-

Mechanistic toxicology :the molecular basis of how chemicals disrupt biological targets /Urs A. Boelsterli. - 2nd ed. - New York :Informa Healthcare,c2009. - 399 p. :ill. ;25 cm.

Includes bibliographical references and index.

Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.

The author provides an introduction to an important, but often neglected, area within the toxicological sciences. The text gives new insights into the processes and mechanisms underlying the toxicity of chemicals and explains how foreign compounds exert their potentially damaging effects on cells and tissues.

ISBN: 9780849372728 (hard) :NT2230Subjects--Topical Terms:

281655
Molecular toxicology.

National Library of Medicine Call No.: QV 602 / B671 2009

Mechanistic toxicology :the molecular basis of how chemicals disrupt biological targets /
LDR:01888cam a2200229 a 4500 001 238618
003 OCoLC
005 20120223084759.0
008 120306s2009 nyua b 001 0 eng
020 $a 9780849372728 (hard) : $c NT2230
020 $a 0849372720
035 $a (OCoLC)475581759
035 $a 23800000002
040 $a KMU $b KMU
049 $a FISA
060 4 $a QV 602 $b B671 2009
100 1 $a Boelsterli, Urs A., $d 1948- $3 311754
245 1 0 $a Mechanistic toxicology : $b the molecular basis of how chemicals disrupt biological targets / $c Urs A. Boelsterli.
250 $a 2nd ed.
260 $a New York : $c c2009. $b Informa Healthcare,
300 $a 399 p. : $b ill. ; $c 25 cm.
504 $a Includes bibliographical references and index.
505 0 $a Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.
520 $a The author provides an introduction to an important, but often neglected, area within the toxicological sciences. The text gives new insights into the processes and mechanisms underlying the toxicity of chemicals and explains how foreign compounds exert their potentially damaging effects on cells and tissues.
650 0 $2 96060 $a Molecular toxicology. $3 281655