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Systems biology in drug discovery and development

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Systems biology in drug discovery and development/ edited by Daniel L. Young, Seth Michelson.
其他作者:	Young, Daniel L.,
出版者:	Hoboken, N.J. :Wiley, : c2012.,
面頁冊數:	1 online resource (xvii, 370 p.) :ill. (some col.). :
Subject:	Drug development. -
Online resource:	An electronic book accessible through the World Wide Web; click for information
ISBN:	9781118016435 (electronic bk.)

Systems biology in drug discovery and development
Systems biology in drug discovery and development[electronic resource] /edited by Daniel L. Young, Seth Michelson. - Hoboken, N.J. :Wiley,c2012. - 1 online resource (xvii, 370 p.) :ill. (some col.). - Wiley series on technologies for the pharmaceutical industry. - Wiley series on technologies for the pharmaceutical industry..

Includes bibliographical references and index.

Frontmatter -- Color Plates -- Introduction to Systems Biology in Approach. Introduction to Systems Biology in Drug Discovery and Development / Seth Michelson, Daniel L Young -- Methods for Biology: Model Construction and Analysis / Theresa Yuraszeck, Peter Chang, Kalyan Gayen, Eric Kwei, Henry Mirsky, Francis J Doyle -- Methods in Biology: Modeling Feedback Dynamics in Pathways / Peter Wellstead, Olaf Wolkenhauer -- Simulation of Population Variability in Pharmacokinetics / Jiansong Yang -- Applications to Drug Discovery. Applications of Systems Biology Approaches to Target Identification and Validation in Drug Discovery / Bart S Hendriks -- Lead Identification and Optimization / Seth Michelson -- Role of Core Biological Motifs in Dose b6 sResponse Modeling: An Example with Switchlike Circuits / Sudin Bhattacharya, Qiang Zhang, Melvin E Andersen -- Mechanism-Based Pharmacokinetic b6 sPharmacodynamic Modeling During Discovery and Early Development / Hans Peter Grimm, Ying Ou, Micaela Reddy, Pascale David-Pierson, Thierry La�v -- Applications to Drug Development. Developing Oncology Drugs Using Virtual Patients of Vascular Tumor Diseases / Zvia Agur, Naamah Bloch, Boris Gorelik, Marina Kleiman, Yuri Kogan, Yael Sagi, D Sidransky, Yael Ronen -- Systems Modeling Applied to Candidate Biomarker Identification / Ananth Kadambi, Daniel L Young, Kapil Gadkar -- Simulating Clinical Trials / Tom Parke -- Synergies with other Technologies. Pathway Analysis in Drug Discovery / Anton Yuryev -- Functional Mapping for Predicting Drug Response and Enabling Personalized Medicine / Yao Li, Wei Hou, Wei Zhao, Kwangmi Ahn, Rongling Wu -- Future Outlook for Systems Biology / Daniel L Young, Seth Michelson -- Index.

Electronic reproduction.
Hoboken, N.J. :
Wiley InterScience,
2011.

Mode of access: World Wide Web.

ISBN: 9781118016435 (electronic bk.)

Source: 10.1002/9781118016435Wiley InterSciencehttp://www3.interscience.wiley.comSubjects--Topical Terms:

232902
Drug development.
Index Terms--Genre/Form:

228523
Electronic books.

LC Class. No.: RM301.25 / .S97 2012eb

Dewey Class. No.: 615/.19

National Library of Medicine Call No.: QV 744

Systems biology in drug discovery and development
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490 1 $a Wiley series on technologies for the pharmaceutical industry
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505 0 $a Frontmatter -- Color Plates -- Introduction to Systems Biology in Approach. Introduction to Systems Biology in Drug Discovery and Development / Seth Michelson, Daniel L Young -- Methods for Biology: Model Construction and Analysis / Theresa Yuraszeck, Peter Chang, Kalyan Gayen, Eric Kwei, Henry Mirsky, Francis J Doyle -- Methods in Biology: Modeling Feedback Dynamics in Pathways / Peter Wellstead, Olaf Wolkenhauer -- Simulation of Population Variability in Pharmacokinetics / Jiansong Yang -- Applications to Drug Discovery. Applications of Systems Biology Approaches to Target Identification and Validation in Drug Discovery / Bart S Hendriks -- Lead Identification and Optimization / Seth Michelson -- Role of Core Biological Motifs in Dose b6 sResponse Modeling: An Example with Switchlike Circuits / Sudin Bhattacharya, Qiang Zhang, Melvin E Andersen -- Mechanism-Based Pharmacokinetic b6 sPharmacodynamic Modeling During Discovery and Early Development / Hans Peter Grimm, Ying Ou, Micaela Reddy, Pascale David-Pierson, Thierry La�v -- Applications to Drug Development. Developing Oncology Drugs Using Virtual Patients of Vascular Tumor Diseases / Zvia Agur, Naamah Bloch, Boris Gorelik, Marina Kleiman, Yuri Kogan, Yael Sagi, D Sidransky, Yael Ronen -- Systems Modeling Applied to Candidate Biomarker Identification / Ananth Kadambi, Daniel L Young, Kapil Gadkar -- Simulating Clinical Trials / Tom Parke -- Synergies with other Technologies. Pathway Analysis in Drug Discovery / Anton Yuryev -- Functional Mapping for Predicting Drug Response and Enabling Personalized Medicine / Yao Li, Wei Hou, Wei Zhao, Kwangmi Ahn, Rongling Wu -- Future Outlook for Systems Biology / Daniel L Young, Seth Michelson -- Index.
505 0 $a Introduction to systems biology in drug discovery and development -- Methods for in silico biology : model construction and analysis -- Methods in in silico biology : modeling feedback dynamics in pathways -- Simulation of population variability in pharmacokinetics -- Applications of systems biology approaches to target identification and validation in drug discovery -- Lead identification and optimization -- The role of core biological motifs in dose-response modeling : an example with switch-like circuits -- Mechanism based pharmacokinetic-pharmacodynamic modeling during discovery and early development -- Developing oncology drugs using virtual patients of vascular tumor diseases -- Systems modeling applied to candidate biomarker identification -- Simulating clinical trials -- Pathway analysis in drug discovery -- Functional mapping for predicting drug response and enabling personalized medicine -- Future outlook of systems biology.
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