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Heterogeneities in Alzheimer's Disea...

Jonson, Caroline,

Heterogeneities in Alzheimer's Disease and Related Dementias: Elucidating the Genetic and Transcriptomic Underpinnings /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Heterogeneities in Alzheimer's Disease and Related Dementias: Elucidating the Genetic and Transcriptomic Underpinnings // Caroline Jonson.
作者:	Jonson, Caroline,
面頁冊數:	1 electronic resource (230 pages)
附註:	Source: Dissertations Abstracts International, Volume: 85-09, Section: B.
提要註:	Despite the tremendous burden of Alzheimer's disease and related dementias (ADRD on patients, their families, and the public health system, there are still no effective treatments for the disease. Seeking a better understanding of important disease-subgroup-specific associations in a highly heterogeneous patient population, like those diagnosed with ADRD, can help facilitate the development of new therapeutics by enhancing clinical trial design. This thesis focuses on elucidating the genetic and transcriptomic underpinnings of the heterogeneities in ADRD and where these subgroups mechanistically converge.Chapter 1 focuses on features driving sex differences in AD progression to help reveal what protects some individuals and what makes others more vulnerable, ultimately informing the development of personalized therapeutics that benefit both sexes.Chapter 2 presents a meta-analysis of Alzheimer's disease genetics across multiple ancestries and highlights the current lack of diversity in neurodegenerative disease genetic research, suggesting a need for more inclusive studies.Chapter 3 links peripheral immune changes to familial tauopathy and early-onset Alzheimer's, showing altered monocytes in tauopathies and increased interferon-responsive T cells in EOAD. This chapter highlights the importance of the immune system in ADRD.
Contained By:	Dissertations Abstracts International85-09B.
標題:	Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30991867
ISBN:	9798381971644

Heterogeneities in Alzheimer's Disease and Related Dementias: Elucidating the Genetic and Transcriptomic Underpinnings /
Jonson, Caroline,

Heterogeneities in Alzheimer's Disease and Related Dementias: Elucidating the Genetic and Transcriptomic Underpinnings /Caroline Jonson. - 1 electronic resource (230 pages)

Source: Dissertations Abstracts International, Volume: 85-09, Section: B.

Despite the tremendous burden of Alzheimer's disease and related dementias (ADRD on patients, their families, and the public health system, there are still no effective treatments for the disease. Seeking a better understanding of important disease-subgroup-specific associations in a highly heterogeneous patient population, like those diagnosed with ADRD, can help facilitate the development of new therapeutics by enhancing clinical trial design. This thesis focuses on elucidating the genetic and transcriptomic underpinnings of the heterogeneities in ADRD and where these subgroups mechanistically converge.Chapter 1 focuses on features driving sex differences in AD progression to help reveal what protects some individuals and what makes others more vulnerable, ultimately informing the development of personalized therapeutics that benefit both sexes.Chapter 2 presents a meta-analysis of Alzheimer's disease genetics across multiple ancestries and highlights the current lack of diversity in neurodegenerative disease genetic research, suggesting a need for more inclusive studies.Chapter 3 links peripheral immune changes to familial tauopathy and early-onset Alzheimer's, showing altered monocytes in tauopathies and increased interferon-responsive T cells in EOAD. This chapter highlights the importance of the immune system in ADRD.

English

ISBN: 9798381971644Subjects--Topical Terms:

187040
Immunology.
Subjects--Index Terms:

Ancestral differences

Heterogeneities in Alzheimer's Disease and Related Dementias: Elucidating the Genetic and Transcriptomic Underpinnings /
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520 $a Despite the tremendous burden of Alzheimer's disease and related dementias (ADRD on patients, their families, and the public health system, there are still no effective treatments for the disease. Seeking a better understanding of important disease-subgroup-specific associations in a highly heterogeneous patient population, like those diagnosed with ADRD, can help facilitate the development of new therapeutics by enhancing clinical trial design. This thesis focuses on elucidating the genetic and transcriptomic underpinnings of the heterogeneities in ADRD and where these subgroups mechanistically converge.Chapter 1 focuses on features driving sex differences in AD progression to help reveal what protects some individuals and what makes others more vulnerable, ultimately informing the development of personalized therapeutics that benefit both sexes.Chapter 2 presents a meta-analysis of Alzheimer's disease genetics across multiple ancestries and highlights the current lack of diversity in neurodegenerative disease genetic research, suggesting a need for more inclusive studies.Chapter 3 links peripheral immune changes to familial tauopathy and early-onset Alzheimer's, showing altered monocytes in tauopathies and increased interferon-responsive T cells in EOAD. This chapter highlights the importance of the immune system in ADRD.
546 $a English
590 $a School code: 0034
650 4 $2 96060 $a Immunology. $3 187040
650 4 $2 96060 $a Molecular biology. $3 214456
650 4 $2 96060 $a Pharmacology. $3 185640
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653 $a Dementias
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653 $a Genomics
653 $a Sex differences
653 $a Transcriptomics
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690 $a 0982
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710 2 $a University of California, San Francisco. $b Pharmaceutical Sciences and Pharmacogenomics. $e degree granting institution. $3 523846
720 1 $a Yokoyama, Jennifer $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 85-09B.
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