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GABA-T Inhibition and Its Effects on...

The University of Arizona.

GABA-T Inhibition and Its Effects on the Progression of Hepatocellular Carcinoma and Aging /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	GABA-T Inhibition and Its Effects on the Progression of Hepatocellular Carcinoma and Aging // Emily Ngu.
作者:	Ngu, Emily,
面頁冊數:	1 electronic resource (58 pages)
附註:	Source: Masters Abstracts International, Volume: 86-07.
提要註:	Outside of its role in the central nervous system as an inhibitory neurotransmitter, ɣ-aminobutyric-acid (GABA) acts as a hepatokine within the liver. NAFLD is associated with increased risk of developing HCC. We have previously demonstrated obesity increases production and excretion of hepatic GABA. Furthermore, GABA can drive the progression of HCC. In regards to aging, obesity shortens lifespan and healthspan, thus contributing to accelerated aging. We performed two studies assessing the effects of GABA-transaminase inhibition on NAFLD-associated HCC and age-associated metabolic and physical declines. To assess the role of GABA within NAFLD-associated HCC, we created an accelerated diet-sensitive mouse model and targeted hepatic GABA production using ethanolamine-O-sulfate (EOS), a GABA-transaminase inhibitor. We found HCC decreased mRNA expression of the GABA shunt enzymes (GABA-transaminase and succinate semialdehyde dehydrogenase), decreased mRNA expression of export-type GABA transporters (SLC6A12 and SCL6A13), and decreased mRNA expression of GABA A receptor subunits. Overall, GABA-transaminase inhibition using EOS had no effect on tumor burden after 16 weeks of exposure to cancer-causing stimuli. To assess the role of GABA in aging, we tested measures of metabolic and physical performance in 6 months-old-, 12 months-old-, and 18 months-old-mice. After administering EOS for 4 weeks, we observed modest improvements to glucose clearance, basal insulin, and all-limb grip strength in aged mice. Additionally, GABA-transaminase inhibition caused weight loss and lowered serum triglycerides in both young and aged mice.
Contained By:	Masters Abstracts International86-07.
標題:	Aging. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31763566
ISBN:	9798302159663

GABA-T Inhibition and Its Effects on the Progression of Hepatocellular Carcinoma and Aging /
Ngu, Emily,

GABA-T Inhibition and Its Effects on the Progression of Hepatocellular Carcinoma and Aging /Emily Ngu. - 1 electronic resource (58 pages)

Source: Masters Abstracts International, Volume: 86-07.

Outside of its role in the central nervous system as an inhibitory neurotransmitter, ɣ-aminobutyric-acid (GABA) acts as a hepatokine within the liver. NAFLD is associated with increased risk of developing HCC. We have previously demonstrated obesity increases production and excretion of hepatic GABA. Furthermore, GABA can drive the progression of HCC. In regards to aging, obesity shortens lifespan and healthspan, thus contributing to accelerated aging. We performed two studies assessing the effects of GABA-transaminase inhibition on NAFLD-associated HCC and age-associated metabolic and physical declines. To assess the role of GABA within NAFLD-associated HCC, we created an accelerated diet-sensitive mouse model and targeted hepatic GABA production using ethanolamine-O-sulfate (EOS), a GABA-transaminase inhibitor. We found HCC decreased mRNA expression of the GABA shunt enzymes (GABA-transaminase and succinate semialdehyde dehydrogenase), decreased mRNA expression of export-type GABA transporters (SLC6A12 and SCL6A13), and decreased mRNA expression of GABA A receptor subunits. Overall, GABA-transaminase inhibition using EOS had no effect on tumor burden after 16 weeks of exposure to cancer-causing stimuli. To assess the role of GABA in aging, we tested measures of metabolic and physical performance in 6 months-old-, 12 months-old-, and 18 months-old-mice. After administering EOS for 4 weeks, we observed modest improvements to glucose clearance, basal insulin, and all-limb grip strength in aged mice. Additionally, GABA-transaminase inhibition caused weight loss and lowered serum triglycerides in both young and aged mice.

English

ISBN: 9798302159663Subjects--Topical Terms:

215852
Aging.
Subjects--Index Terms:

Hepatocellular carcinoma

GABA-T Inhibition and Its Effects on the Progression of Hepatocellular Carcinoma and Aging /
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