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Mechanistic toxicology :the molecula...

Boelsterli, Urs A., (1948-)

Mechanistic toxicology :the molecular basis of how chemicals disrupt biological targets /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Mechanistic toxicology :/ Urs A. Boelsterli.
其他題名:	the molecular basis of how chemicals disrupt biological targets /
作者:	Boelsterli, Urs A.,
出版者:	New York :Informa Healthcare, : c2009.,
版本:	2nd ed.
面頁冊數:	399 p. :ill. ; : 25 cm.;
提要註:	The author provides an introduction to an important, but often neglected, area within the toxicological sciences. The text gives new insights into the processes and mechanisms underlying the toxicity of chemicals and explains how foreign compounds exert their potentially damaging effects on cells and tissues.
標題:	Molecular toxicology. -
ISBN:	9780849372728 (hard) :

Mechanistic toxicology :the molecular basis of how chemicals disrupt biological targets /
Boelsterli, Urs A.,1948-

Mechanistic toxicology :the molecular basis of how chemicals disrupt biological targets /Urs A. Boelsterli. - 2nd ed. - New York :Informa Healthcare,c2009. - 399 p. :ill. ;25 cm.

Includes bibliographical references and index.

Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.

The author provides an introduction to an important, but often neglected, area within the toxicological sciences. The text gives new insights into the processes and mechanisms underlying the toxicity of chemicals and explains how foreign compounds exert their potentially damaging effects on cells and tissues.

ISBN: 9780849372728 (hard) :NT2230Subjects--Topical Terms:

281655
Molecular toxicology.

National Library of Medicine Call No.: QV 602 / B671 2009

Mechanistic toxicology :the molecular basis of how chemicals disrupt biological targets /
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003 OCoLC
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008 120306s2009 nyua b 001 0 eng
020 $a 9780849372728 (hard) : $c NT2230
020 $a 0849372720
035 $a (OCoLC)475581759
035 $a 23800000002
040 $a KMU $b KMU
049 $a FISA
060 4 $a QV 602 $b B671 2009
100 1 $a Boelsterli, Urs A., $d 1948- $3 311754
245 1 0 $a Mechanistic toxicology : $b the molecular basis of how chemicals disrupt biological targets / $c Urs A. Boelsterli.
250 $a 2nd ed.
260 $a New York : $c c2009. $b Informa Healthcare,
300 $a 399 p. : $b ill. ; $c 25 cm.
504 $a Includes bibliographical references and index.
505 0 $a Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.
520 $a The author provides an introduction to an important, but often neglected, area within the toxicological sciences. The text gives new insights into the processes and mechanisms underlying the toxicity of chemicals and explains how foreign compounds exert their potentially damaging effects on cells and tissues.
650 0 $2 96060 $a Molecular toxicology. $3 281655