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Utilizing Zebrafish for a Multifacet...

The University of Utah.

Utilizing Zebrafish for a Multifaceted Approach to Modulate Lipid Metabolism in Metabolic-Dysfunction-Associated Steatotic Liver Disease and Hepatocellular Carcinoma /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Utilizing Zebrafish for a Multifaceted Approach to Modulate Lipid Metabolism in Metabolic-Dysfunction-Associated Steatotic Liver Disease and Hepatocellular Carcinoma // Chad Hilton VanSant-Webb.
作者:	VanSant-Webb, Chad Hilton,
面頁冊數:	1 electronic resource (209 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-05, Section: B.
提要註:	Liver cancer or hepatocellular carcinoma (HCC) is a leading cause of cancer-related death with a poor prognosis and short 5-year survival. Metabolic disorders such as obesity and metabolic-dysfunction-associated steatotic liver disease (MASLD) are associated with a 2-fold increase of risk of developing HCC. Since the incidence of obesity and MASLD have and will continue to increase, the incidence of HCC is increasing as well. Much like the tumors themselves, HCC as a whole is a heterogeneous disease with a diverse array of risk factors and etiologies that are uniquely exacerbated by social inequalities, which has made the field of HCC research particularly challenging.To address the central role that dysregulated metabolism plays in disease risk and progression and to acknowledge these challenges, the strength of zebrafish was leveraged to model lipid metabolism using a multi-faceted approach. Herein a transgenic model of activated β-catenin-driven (ABC) HCC that recapitulates disease as seen in 30-40% of human HCC was utilized to describe new methods to identify the effects of ABC on lipid metabolic reprogramming, to screen metabolic inhibitors to identify potential therapeutic targets and uncover molecular mechanisms of disease, and to characterize and model the dysregulation of microRNAs on the hepatocyte transcriptome. Unexpectedly, this research uncovered a potentially unifying theme, the potential of sex-based differences in lipid metabolism and inflammation, which is concordant with what has been documented in higher mammals and humans.
Contained By:	Dissertations Abstracts International86-05B.
標題:	Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31301852
ISBN:	9798342714556

Utilizing Zebrafish for a Multifaceted Approach to Modulate Lipid Metabolism in Metabolic-Dysfunction-Associated Steatotic Liver Disease and Hepatocellular Carcinoma /
VanSant-Webb, Chad Hilton,

Utilizing Zebrafish for a Multifaceted Approach to Modulate Lipid Metabolism in Metabolic-Dysfunction-Associated Steatotic Liver Disease and Hepatocellular Carcinoma /Chad Hilton VanSant-Webb. - 1 electronic resource (209 pages)

Source: Dissertations Abstracts International, Volume: 86-05, Section: B.

Liver cancer or hepatocellular carcinoma (HCC) is a leading cause of cancer-related death with a poor prognosis and short 5-year survival. Metabolic disorders such as obesity and metabolic-dysfunction-associated steatotic liver disease (MASLD) are associated with a 2-fold increase of risk of developing HCC. Since the incidence of obesity and MASLD have and will continue to increase, the incidence of HCC is increasing as well. Much like the tumors themselves, HCC as a whole is a heterogeneous disease with a diverse array of risk factors and etiologies that are uniquely exacerbated by social inequalities, which has made the field of HCC research particularly challenging.To address the central role that dysregulated metabolism plays in disease risk and progression and to acknowledge these challenges, the strength of zebrafish was leveraged to model lipid metabolism using a multi-faceted approach. Herein a transgenic model of activated β-catenin-driven (ABC) HCC that recapitulates disease as seen in 30-40% of human HCC was utilized to describe new methods to identify the effects of ABC on lipid metabolic reprogramming, to screen metabolic inhibitors to identify potential therapeutic targets and uncover molecular mechanisms of disease, and to characterize and model the dysregulation of microRNAs on the hepatocyte transcriptome. Unexpectedly, this research uncovered a potentially unifying theme, the potential of sex-based differences in lipid metabolism and inflammation, which is concordant with what has been documented in higher mammals and humans.

English

ISBN: 9798342714556Subjects--Topical Terms:

192833
Nutrition.
Subjects--Index Terms:

Hepatocellular carcinoma

Utilizing Zebrafish for a Multifaceted Approach to Modulate Lipid Metabolism in Metabolic-Dysfunction-Associated Steatotic Liver Disease and Hepatocellular Carcinoma /
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653 $a miRNA
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